Ol’ Billy Blue Eyes Unleashes: 10 Times Bill Burr ‘Destroyed’ Talk Show Hosts with Hilarious Roasts

From casual small talk to a full-blown verbal sparring match, Bill Burr has a legendary knack for turning a standard talk show interview into an unforgettable, unfiltered masterclass in comedy. The moment a host shows an ounce of feigned concern or an unearned moral high ground, Burr is ready to pounce.

Here are ten times Bill Burr completely roasted and dismantled talk show hosts, leaving a trail of shattered egos and awkward laughter in his wake.

1. The “Motherhood” Myth vs. Oil Rig Workers

Burr has never met a sacred cow he wasn’t willing to barbecue. When a host brought up Oprah Winfrey’s famous quote that being a mother is “the hardest job in the world,” Burr went straight for the jugular with an unbelievable comparison.

“No. It’s not the most difficult job on the planet. It just isn’t.”

He then compared the “fussy toddler” struggles to oil rig workers who are “on fire” and have to “jump into water that’s on fire” before “praying to God that the Coast Guard is going to get there before the sharks do.”

His closing line? You don’t get the same heartwarming payoff for working on a rig “when your buddy’s greasy face lights up.”

2. Calling Out Oprah’s Hypocrisy on Lance Armstrong

Burr wasn’t done with Oprah. In a separate interview, he blasted her for acting “dumbfounded” during her interview with Lance Armstrong about his doping scandal.

“She’s been in show business for 35 years and she can’t like wrap her head around some guy doing whatever it takes to get to the next level?”

He savagely recalled the early days of her show, suggesting she built her empire by having “midgets who wanted to bang their mailman’s boyfriend,” implying she stood “on the heads of those little people” before claiming moral outrage.

3. The “Happiness” Inquiry That Backfired on Jimmy Kimmel

A simple, innocuous question about happiness quickly became Burr’s ammunition against Jimmy Kimmel.

Kimmel asked, “Do you have trouble with happiness? Is that hard for you?”

Burr immediately shot back, calling out the host’s performance:

“I’ll tell you what bugged me was your fake concern there. The way you… leaned in and you squinted your face. No, I don’t have a problem being happy. I have a great time being happy as long as nobody asked me that question.”

4. Defending His Religious Jokes by Roasting the Catholic Church

When a host brought up complaints that Burr had been “disrespectful to the Christian religion,” Burr flipped the script by attacking the host’s priorities and the very institution they were defending.

“Don’t you think the Catholic Church went a little too far? More so than my cartoon. A couple of jokes. I know this is a morning show. You can’t bring up all those crimes.”

He then compared the church moving abusive priests to how SeaWorld handles killer whales after they attack a trainer: they “just sort of kept moving them around.”

5. Conan O’Brien’s ‘Sitcom Dad’ Attire

On Conan O’Brien’s show, Burr immediately fixated on the host’s footwear and socks, turning a discussion about fashion into a full-blown character assassination.

“You have athletic soles on your wing tips… Gold toe socks. I’m a banker. What are you, a sitcom dad in the ’50s? ‘Honey, I’m home! Hello! I got a new company car. Ah, it’s great to be white!’”

He then skewered the co-host for her overly empathetic tone, saying she sounded like she was “watching a rescue dog commercial.”

6. Challenging Sarah Silverman’s ‘I Love You’ Text Memory

When his friend Sarah Silverman introduced him by saying they fight like siblings but she loves him, Burr went right to an uncomfortable truth—or a lack thereof.

He claimed that every time they fight, he gets a text from her saying, “You know I love you, right?”

When Silverman denied sending those texts, Burr’s confusion turned aggressive:

“That isn’t me. Are you fing serious?*… Oh, I never do [delete texts] because all our friends die and then it’s all you have left.”

7. Blasting Bobby Lee’s ‘Little Panda Hand’ and False Discovery Claim

Burr’s appearance on a podcast with Bobby Lee started with the host’s bizarre and unsolicited question about his bald head: “Did you shave your head for a part?”

Burr immediately took control:

“I’m bald. I’m just asking you a question… I love how you came at me aggressive and now you’re going, you got your p… your little panda hand.”

Lee then tried to claim he “discovered” Burr, prompting a furious response: “I remember it was a big day in my career. Bobby Lee is finally aware of me.”

8. Colin Cowherd’s “Real Housewife Question”

Even a sports talk show host like Colin Cowherd couldn’t escape Burr’s scrutiny. When Cowherd tried to frame a question about Tom Brady’s success as a “sticking it to the system” moment for Boston fans, Burr crushed the premise.

“Oh, this is such a real housewife question. Is his victory somebody else’s defeat? I don’t You hate Boston. I get it… I’m sorry you went on the Freedom Trail and uh you didn’t get to meet Paul Revere or whatever they promised you.”

He finished the segment by ripping Cowherd’s unconfirmed sports “theory,” throwing the host entirely off-balance.

9. Turning a Silly Cereal Quiz into an Anti-Establishment Rant

Appearing on a morning show the week before the Super Bowl, the hosts tried to play it safe with a quiz about famous cereal mascots. Burr, however, refused to play the game.

First, he described the Super Bowl week as “the Oscars for prostitutes,” forcing the host to pivot to “safer subjects.”

When shown a picture of the Quaker Oats man:

“That’s one of the founding fathers who said that all men are created equal as long as they’re white.”

10. Labeling Howie Mandel’s Life a ‘Pillow’ While Trashing His Judging Career

Burr’s interview with Howie Mandel was pure aggression from the jump. When Burr questioned his violet-tinted glasses, Mandel tried to explain they were for headaches.

Burr’s take:

“Because you, you like, live life on a pillow and you just, you walk around like you’re in a war zone… You’re very, you’re very sensitive.”

He then delivered the ultimate roast of Mandel’s second career as a reality TV judge: “But this is that way you go on TV and judge other artists to make you feel like a big man.” When Mandel called Burr “a lot,” Burr agreed, delivering a self-aware, brutal truth:

“It’s not about talent, Howie… It’s do I want to be around this person? Do I want to deal with this guy 14 hours a day? And sometimes you’re on the fence and other times it’s just an obvious no.”

The takeaway? If you invite Bill Burr onto your show, you better leave your filter at home, or he’ll make you wish you had.